refaaxis.blogg.se - Action potential graph

Action potential graph Patch#
Action potential graph full#

If you look at the graph of sodium current and line it up with the graph of the action potential, you will see that the dip in the sodium current coincides with the peak of the action potential. With two phases and a prominent inflection point (the "notch" in the current that coincides with the peak of the action potential)? The sodium conductance simply rises and then falls,īut the current rises, then falls, then rises and falls again. Why is the graph of the sodium current, INa so "curvy", The shape of the sodium and potassium currents (I Na There are several important features of sodium and potassiumĬurrents which are apparent from these conductance plots. May only be calculated in simulations like this one.) Now run the simulation again. With a current clamp or even with a voltage clamp in a real experiment. (Again, you could not make these observations of conductance

Action potential graph Patch#

K conductances (Patch gNa and Patch gK) asĪ function of time. Now observe the conductances changing during the action potential.īring up a third graph, plotting the Na and.In the next simulation) in contrast, the individual currentsįlowing during the complicated voltage change of the action potential cannotīe measured experimentally, but can only be calculated, as NEURON is doing The relatively simple stimulus of a voltage step, (a paradigm we will explore The voltage clamp measures currents in response to These action potential current patterns are not the same as those observed If you are familiar with voltage clamp experiments, you will note that You will see graphs ofĬurrents (patch INa and patch IK) that cause the rise and fall of the action To do this, press Membrane Current Plots to bring up a second Observe the currents underlying the action potential.Ek (the potassium equilibrium potential).On the graph of the membrane potential vs. You will see an action potential displayed Press Reset & Run to run the simulation.The Stimulus Control panel must open to deliver a stimulus.

The easiest thing to do in this case is to quit from the program and start it again.

If you have a problem with the program: sometimes the simulation program can get hung up, usually because some parameter was accidentally changed.

Other functions of the simulations are explained as Run a simulation by pressing Reset & Run in the RunĬontrol panel. The top of this panel to view or change the duration, amplitude or onset of To deliver a stimulus, you must open the StimulusĬontrol Panel (by pressing the button on the Panel and Graph Store, erase, resize, and measure traces in these plotting Open a graph for the first simulation by hitting the Voltage vs. Manager opens up other panels and graphs of voltage, current or conductance This tutorial assumes that you familiar with the basic panels and manipulationsĪs in previous tutorials, the Panel and Graph You will be prompted onscreen with hints and occasional verbal abuse until you get the right answer. Left for you to answer online in the spaces provided.

Action potential graph full#

Like previous tutorials, this one is full of questions.answers to some of

To change the out and observe the effect on the peak and timecourse.

To understand how conductance and driving force interact to shape ion currents.

To observe the action potential, and its underlying currents and conductance.

We will be lookingĪt the non-propagating action potential in a patch (sometimes called the "membraneĪction potential"), which is easier to understand than the propagating action Regenerative voltage response that can be provoked by a variety of stimuli.